2237230-21-4
2237230-21-4
Chemical Structure
EGFR/HER2-IN-12
- CAS No.: 2237230-21-4
- Formula:C25H17ClN4O3S
- Molecular Weight:488.95
InChIKey: CXNQMGSBTYPPQZ-UHFFFAOYSA-N
SMILES: O=[N+]([O-])C1=CC=C(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OC5=CC=CC(C)=C5)N=CN=C3S2)C=C1
Biological Activity: EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant[1].
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EGFR/HER2-IN-12 | EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant. | |||||||||||||||||||||
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