2237269-22-4
Chemical Structure
NAMPT activator-10
- CAS No.: 2237269-22-4
- Formula:C20H20N4O4S
- Molecular Weight:412.46
InChIKey: MCGLOVSUCKXDOC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)NS(=O)(C2=CC=C(C=C2)OC)=O)NCC3=CC=NC=C3
Biological Activity: NAMPT activator-10 (Compound B11) is an orally active NAMPT activator with a target Kd value of 0.64 μM. NAMPT activator-10 activates the rate-limiting enzyme in NAD+ biosynthesis and promotes intracellular NAD+ synthesis. NAMPT activator-10 reduces lactate accumulation, enhances glycogen storage in the liver and muscle, increases tissue ATP production, improves exercise endurance and muscle strength, and exerts a protective effect against fatigue-induced muscle damage in mouse fatigue models. NAMPT activator-10 can be used in studies related to muscle fatigue[1].
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NAMPT activator-10 | NAMPT activator-10 (Compound B11) is an orally active NAMPT activator with a target Kd value of 0.64 μM. NAMPT activator-10 activates the rate-limiting enzyme in NAD+ biosynthesis and promotes intracellular NAD+ synthesis. NAMPT activator-10 reduces lactate accumulation, enhances glycogen storage in the liver and muscle, increases tissue ATP production, improves exercise endurance and muscle strength, and exerts a protective effect against fatigue-induced muscle damage in mouse fatigue models. NAMPT activator-10 can be used in studies related to muscle fatigue. | |||||||||||||||||||||
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