2241283-11-2
2241283-11-2
Chemical Structure
Anticancer agent 147
- CAS No.: 2241283-11-2
- Formula:C32H40BrN3O2
- Molecular Weight:578.58
InChIKey: FOCQGOGINGOWMF-NLSFLGDASA-N
SMILES: COC(CCC[C@]1([H])[C@]2([H])[C@]3([H])[C@@](CCCN3CCC2)([H])CN1CC(C4=C5C=CC=C4)=CN5CC6=CC=C(Br)C=C6)=O
Biological Activity: Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].
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Anticancer agent 147 | Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo. | |||||||||||||||||||||
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