2241664-16-2
2241664-16-2
Chemical Structure
JNJ4796
- CAS No.: 2241664-16-2
- Formula:C28H27N9O3
- Molecular Weight:537.57
IUPAC Name: (R)-N-(2-(2-(4-((2-methyl-2H-tetrazol-5-yl)(phenyl)methyl)piperazine-1-carbonyl)pyridin-4-yl)benzo[d]oxazol-5-yl)acetamide
InChIKey: VMAAUIZLAZYALS-RUZDIDTESA-N
SMILES: CC(NC1=CC=C(OC(C2=CC(C(N3CCN([C@@H](C4=NN(C)N=N4)C5=CC=CC=C5)CC3)=O)=NC=C2)=N6)C6=C1)=O
Biological Activity: JNJ4796 is an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ4796 | 99.94% | JNJ4796 is an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs). | ||||||||||||||||||||
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SIRT1/2/3-IN-2 | SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma. | |||||||||||||||||||||
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TNKS-IN-2 | TNKS-IN-2 (compound 40) is a potent and selective tankyrase (TNKS) inhibitor with pIC50 values of 8.1, 7.0 for TANKS and Wnt, respectively. | |||||||||||||||||||||
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TP-680 | TP-680 is a cholecystokinin receptor antagonist. TP-680 binds 1510 times more strongly to rat pancreatic CCKA receptors (IC50=1.2 nM) than to rat brain CCKB receptors (IC50=1812.5 nM). TP-680 can be used in the study of gastrointestinal diseases. | |||||||||||||||||||||
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TLX agonist 1 | 99.94% | TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity. | ||||||||||||||||||||
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IMPDH2-IN-2 | 99.89% | IMPDH2-IN-2 is an inhibitor of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase 2 (MtbIMPDH2) with a Ki,app value of 14 nM. IMPDH2-IN-2 blocks guanine nucleotide biosynthesis and exhibits antibacterial activity against Mycobacterium tuberculosis. IMPDH2-IN-2 can be used for research on tuberculosis. | ||||||||||||||||||||
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CFTR activator 1 | 99.94% | CFTR activator 1 is a potent and selective CFTR activator, with an EC50 of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease. | ||||||||||||||||||||
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UNC9512 | 98.90% | UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing. | ||||||||||||||||||||
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Antibacterial agent 223 | Antibacterial agent 223 (compound D8-03) is an inhibitor of Francisella tularensis. Antibacterial agent 223 can inhibit intracellular growth of Francisella tularensis in mice. | |||||||||||||||||||||
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Progranulin modulator-3 | 99.95% | Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research. | ||||||||||||||||||||
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PAR-2-IN-2 | PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC50 of 10.79 μM for SLIGKV and an IC50 of greater than 200 μM for Trypsin. | |||||||||||||||||||||
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