2242031-31-6
2242031-31-6
Chemical Structure
JAK-2/3-IN-3
- CAS No.: 2242031-31-6
- Formula:C13H10Cl2N4O2
- Molecular Weight:325.15
IUPAC Name: 6,7-dichloro-3-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)quinoxalin-2(1H)-one
InChIKey: PEFXXRLXFDBZEK-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N=C1C3=C(N(C)N=C3C)O)C=C(Cl)C(Cl)=C2
Biological Activity: JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia[1].
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JAK-2/3-IN-3 | JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia. | |||||||||||||||||||||
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