2243516-99-4
Chemical Structure
Urease-IN-24
- CAS No.: 2243516-99-4
- Formula:C14H16N2O3Se
- Molecular Weight:339.25
InChIKey: BBTBTECFWXDPNI-UHFFFAOYSA-N
SMILES: CCOC(C1=C(C)NC(NC1C2=CC(O)=CC=C2)=[Se])=O
Biological Activity: Urease-IN-24 is a cryptococcal urease inhibitor with a IC50 of 89.96 nM and a Ki of 64.3 nM. Urease-IN-24 acts as a competitive nickel-coordinating inhibitor that coordinates with the nickel center at the catalytic site of the enzyme via its carbonyl group. Urease-IN-24 reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases cell membrane permeability, and inhibits melanin production. Urease-IN-24 exhibits fungicidal activity against Cryptococcus species. Urease-IN-24 can be used in the research of cryptococcosis[1].
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Urease-IN-24 | Urease-IN-24 is a cryptococcal urease inhibitor with a IC50 of 89.96 nM and a Ki of 64.3 nM. Urease-IN-24 acts as a competitive nickel-coordinating inhibitor that coordinates with the nickel center at the catalytic site of the enzyme via its carbonyl group. Urease-IN-24 reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases cell membrane permeability, and inhibits melanin production. Urease-IN-24 exhibits fungicidal activity against Cryptococcus species. Urease-IN-24 can be used in the research of cryptococcosis. | |||||||||||||||||||||
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