2244235-49-0
Chemical Structure
Taniborbactam hydrochloride
Synonym(s): VNRX-5133 hydrochloride
- CAS No.: 2244235-49-0
- Formula:C19H30BCl2N3O5
- Molecular Weight:462.18
IUPAC Name: (R)-3-(2-((1r,4R)-4-((2-aminoethyl)amino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid dihydrochloride
InChIKey: CKWIMFZHNCBHIX-DKZBTPFISA-N
SMILES: OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O.[H]Cl.[H]Cl
Biological Activity: Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria[1][2].
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Taniborbactam hydrochloride | 99.97% | Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria. | ||||||||||||||||||||
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Taniborbactam hydrochloride (Standard) | ≥98% | Taniborbactam hydrochloride (Standard) is the analytical standard of Taniborbactam (hydrochloride) (HY-109124A). This product is intended for research and analytical applications. Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria. | ||||||||||||||||||||
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References
- [1]. Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556. [Content Brief]
- [2]. Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16. [Content Brief]
