224427-79-6
Chemical Structure
Nafuredin A
- CAS No.: 224427-79-6
- Formula:C22H32O4
- Molecular Weight:360.49
InChIKey: NMEGHQQRWKBPQO-IMNRXHEYSA-N
SMILES: C[C@@]12[C@@]([C@H](C(O[C@@H]2/C=C/C=C/[C@H](C)C/C(C)=C/C=C/[C@@H](C)CC)=O)O)([H])O1
Biological Activity: Nafuredin A is a trinorsesquiterpene and polyketide derivative found in the mangrove sediment-derived fungi Talaromyces sp. SCSIO 41412 and Trichoderma harzianum D13. Nafuredin A regulates the ferroptosis pathway and upregulates ferroptosis-related genes. Nafuredin A alleviates hypoxia-reoxygenation-induced injury in oxygen-glucose deprivation/reperfusion cell models. Nafuredin A reduces pro-inflammatory cytokines and exerts hepatoprotective effects in animal models of hepatic ischemia-reperfusion injury. Nafuredin A inhibits the growth of phytopathogenic fungi Magnaporthe oryzae and Valsa mali. Nafuredin A can be used in studies related to hepatic ischemia-reperfusion injury and phytopathogenic fungal infections[1][2].
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Nafuredin A | Nafuredin A is a trinorsesquiterpene and polyketide derivative found in the mangrove sediment-derived fungi Talaromyces sp. SCSIO 41412 and Trichoderma harzianum D13. Nafuredin A regulates the ferroptosis pathway and upregulates ferroptosis-related genes. Nafuredin A alleviates hypoxia-reoxygenation-induced injury in oxygen-glucose deprivation/reperfusion cell models. Nafuredin A reduces pro-inflammatory cytokines and exerts hepatoprotective effects in animal models of hepatic ischemia-reperfusion injury. Nafuredin A inhibits the growth of phytopathogenic fungi Magnaporthe oryzae and Valsa mali. Nafuredin A can be used in studies related to hepatic ischemia-reperfusion injury and phytopathogenic fungal infections. | |||||||||||||||||||||
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References
- [1]. Lan W, et al. Discovery of a Hepatoprotective Trinor-Sesterterpenoid from the Marine Fungus sp. Against Hepatic Ischemia-Reperfusion Injury. Marine drugs. 2025 Aug 16;23(8):329. [Content Brief]
- [2]. Zhao D L, et al. Antifungal Nafuredin and Epithiodiketopiperazine Derivatives From the Mangrove-Derived Fungus Trichoderma harzianum D13. Frontiers in Microbiology, 2020, 11: 01495.
