224445-12-9
Chemical Structure
Bis(7)-tacrine dihydrochloride
- CAS No.: 224445-12-9
- Formula:C33H42Cl2N4
- Molecular Weight:565.62
IUPAC Name: N1,N7-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine dihydrochloride
InChIKey: RHKXINFBJWDTSK-UHFFFAOYSA-N
SMILES: [H]N(C1=C2C(C=CC=C2)=NC3=C1CCCC3)CCCCCCCN(C4=C5C=CC=CC5=NC6=C4CCCC6)[H].Cl.Cl
Biological Activity: Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease [1][2][3].
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Bis(7)-tacrine dihydrochloride | 99.9% | Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease . | ||||||||||||||||||||
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References
- [1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32. [Content Brief]
- [2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800. [Content Brief]
- [3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509. [Content Brief]
