2245082-05-5
2245082-05-5
Chemical Structure
Sitneprotafib
Synonym(s): JAB-3312
- CAS No.: 2245082-05-5
- Formula:C21H22ClN7S
- Molecular Weight:439.96
InChIKey: GKGIGIUNYOFYHZ-LJQANCHMSA-N
SMILES: N[C@H](C(C=CC=N1)=C1C2)C2(CC3)CCN3C(N=C4)=CN=C4SC5=C(Cl)C(N)=NC=C5
Biological Activity: Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model[1].
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Sitneprotafib | 99.64% | Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model. | ||||||||||||||||||||
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