2245887-38-9
Chemical Structure
DI-591
- CAS No.: 2245887-38-9
- Formula:C31H47N5O4S
- Molecular Weight:585.80
IUPAC Name: (S)-N-((S)-1-cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide
InChIKey: CNJKDQGPBAWNRY-IZZNHLLZSA-N
SMILES: O=C(N[C@@H](C1CCCCC1)CNC(CCN2CCOCC2)=O)[C@@H](NC(CC)=O)CC3=NC4=CC=C(C(C)C)C=C4S3
Biological Activity: DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DI-591 | 98.06% | DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members. | ||||||||||||||||||||
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