2247127-79-1
2247127-79-1
Chemical Structure
Glutaminase-IN-1
Synonym(s): CB839 derivative
- CAS No.: 2247127-79-1
- Formula:C26H24F3N7O3Se
- Molecular Weight:618.47
IUPAC Name: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-selenadiazol-2-yl)acetamide
InChIKey: KWZUDGWKTNIKJY-UHFFFAOYSA-N
SMILES: O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)[Se]1)CC4=NC=CC=C4
Biological Activity: Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glutaminase-IN-1 | 98.09% | Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity. | ||||||||||||||||||||
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