2247688-87-3
2247688-87-3
Chemical Structure
Akt1-IN-8
- CAS No.: 2247688-87-3
- Formula:C21H25Br2N7O
- Molecular Weight:551.28
InChIKey: RNVXPRJSRCEPIX-UHFFFAOYSA-N
SMILES: O=C(C(CNC(C)C)C1=CC=C(C=C1)Br)N2CCN(CC2)C3=C4C(Br)=NNC4=NC=N3
Biological Activity: Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels[1].
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Akt1-IN-8 | Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels. | |||||||||||||||||||||
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