2248703-42-4
Chemical Structure
SACLAC
- CAS No.: 2248703-42-4
- Formula:C20H40ClNO3
- Molecular Weight:377.99
InChIKey: XDHVKWVHTCINMB-RBUKOAKNSA-N
SMILES: CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(CCl)=O
Biological Activity: SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SACLAC | 99.70% | SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models. | ||||||||||||||||||||
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References
- [1]. Yadira F Ordóñez, et al. Activity-Based Imaging of Acid Ceramidase in Living Cells. J Am Chem Soc. 2019 May 15;141(19):7736-7742. [Content Brief]
- [2]. Jennifer M Pearson, et al. Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. Mol Cancer Res. 2020 Mar;18(3):352-363. [Content Brief]
