2250419-19-1
Chemical Structure
IR820-PTX
- CAS No.: 2250419-19-1
- Formula:C99H112N4NaO21S2+
- Molecular Weight:1781.08
InChIKey: GOMXEQWQNZYYCQ-CMECTGEHSA-N
SMILES: CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC([C@H](OC(CCCCCNC5=C(/C=C/C6=[N+](C7=C(C8=CC=CC=C8C=C7)C6(C)C)CCCCS(=O)(O[Na])=O)CCC/C5=C\C=C9N(C%10=C(C%11=CC=CC=C%11C=C%10)C\9(C)C)CCCCS(=O)(O)=O)=O)[C@H](C%12=CC=CC=C%12)NC(C%13=CC=CC=C%13)=O)=O)C)C)O)OC(C%14=CC=CC=C%14)=O)=O
Biological Activity: IR820-PTX, an IR-820 (HY-136886)-Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy[1][2].
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IR820-PTX | IR820-PTX, an IR-820 (HY-136886)-Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy. | |||||||||||||||||||||
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References
- [1]. Zhang D, et al. pH- and Enzyme-Sensitive IR820-Paclitaxel Conjugate Self-Assembled Nanovehicles for Near-Infrared Fluorescence Imaging-Guided Chemo-Photothermal Therapy. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30092-30102. [Content Brief]
- [2]. Yu-Xia Luan, et al. Preparation method and application of amphiphilic small molecule prodrug of ir820-ptx combined with photothermal therapy and chemotherapy and its nanoparticles. CN108727353B.
