2251017-69-1
2251017-69-1
Chemical Structure
Orexin receptor antagonist 4
- CAS No.: 2251017-69-1
- Formula:C23H25FN4O2
- Molecular Weight:408.47
IUPAC Name: 6-((3aS,4S,6aR)-5-(2-fluoro-4-methoxybenzoyl)-4-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2,4-dimethylnicotinonitrile
InChIKey: ZEZLMRDIDIXPJQ-YRNRMSPPSA-N
SMILES: [H][C@@]12CN(C[C@@]1(CN([C@H]2C)C(C3=CC=C(C=C3F)OC)=O)[H])C4=NC(C)=C(C(C)=C4)C#N
Biological Activity: Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].
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Orexin receptor antagonist 4 | Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1). | |||||||||||||||||||||
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