2252242-32-1
Chemical Structure
RAS GTPase inhibitor 1
- CAS No.: 2252242-32-1
- Formula:C27H28ClF4N5O2
- Molecular Weight:565.99
IUPAC Name: (R)-N2-(3-chloro-4-fluorophenyl)-N4-(1-cyclopropylpropyl)-8-(1,2,3,6-tetrahydropyridin-4-yl)quinazoline-2,4-diamine 2,2,2-trifluoroacetate
InChIKey: LEDWHIWAVNXCBJ-VZYDHVRKSA-N
SMILES: CC[C@@H](NC1=C2C=CC=C(C3=CCNCC3)C2=NC(NC4=CC=C(F)C(Cl)=C4)=N1)C5CC5.O=C(O)C(F)(F)F
Biological Activity: RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells[1].
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RAS GTPase inhibitor 1 | RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells. | |||||||||||||||||||||
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