2252341-45-8
Chemical Structure
CLR/RAMP3-receptor antagonist-1
- CAS No.: 2252341-45-8
- Formula:C31H35N5O3
- Molecular Weight:525.64
InChIKey: CKZLNCWDRQNNEQ-WJOKGBTCSA-N
SMILES: O=C1[C@]2(CC3=CC(NC(CN(C(C(C)(C)C)=O)CC4=C(C=CC=C4)CNC)=O)=CC=C3C2)C5=CC=CN=C5N1
Biological Activity: CLR/RAMP3-receptor antagonist-1 is a selective antagonist of the CLR/RAMP3 receptor (CLR/RAMP3, AM2 receptor), with pIC50 values of 5.86, 9.21 and 9.07 against AM1 (CLR/RAMP2), AM2 (CLR/RAMP3) and CGRP (CLR/RAMP1) receptors, respectively. CLR/RAMP3-receptor antagonist-1 reduces the levels of pancreatic cancer progression markers, induces apoptosis in vitro, and prolongs survival in mouse models of pancreatic cancer. CLR/RAMP3-receptor antagonist-1 can be used in pancreatic cancer-related research[1].
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CLR/RAMP3-receptor antagonist-1 | CLR/RAMP3-receptor antagonist-1 is a selective antagonist of the CLR/RAMP3 receptor (CLR/RAMP3, AM2 receptor), with pIC50 values of 5.86, 9.21 and 9.07 against AM1 (CLR/RAMP2), AM2 (CLR/RAMP3) and CGRP (CLR/RAMP1) receptors, respectively. CLR/RAMP3-receptor antagonist-1 reduces the levels of pancreatic cancer progression markers, induces apoptosis in vitro, and prolongs survival in mouse models of pancreatic cancer. CLR/RAMP3-receptor antagonist-1 can be used in pancreatic cancer-related research. | |||||||||||||||||||||
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