22594-69-0
22594-69-0
Chemical Structure
Tricarbonyldichlororuthenium(II) dimer
Synonym(s): CORM-2
- CAS No.: 22594-69-0
- Formula:C6H6Cl4O6Ru2
- Molecular Weight:512.01
InChIKey: DFIVJTIPABJZOF-UHFFFAOYSA-L
SMILES: [O]#C[Ru+2](C#[O])([Cl-])([Cl-][Ru+2]1(C#[O])(C#[O])([Cl-])C#[O])([Cl-]1)C#[O]
Biological Activity: Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tricarbonyldichlororuthenium(II) dimer | 98.0% | Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels. | ||||||||||||||||||||
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References
- [1]. Dong DL, et al. Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. Eur J Pharmacol. 2008 Aug 20;590(1-3):99-104. [Content Brief]
- [2]. Choi EY, et al. Tricarbonyldichlororuthenium(II) dimer, the lipid-soluble carbon monoxide-releasing molecule, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages. Int Immunopharmacol. 2021 Jan;90:107190. [Content Brief]
- [3]. Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208. [Content Brief]
- [4]. Gessner G, et al. CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2). Eur J Pharmacol. 2017 Nov 15;815:33-41. [Content Brief]
