2267318-43-2
Chemical Structure
NWL-117
- CAS No.: 2267318-43-2
- Formula:C29H42N4O11S
- Molecular Weight:654.73
IUPAC Name: (5S,8S,11S,14R)-11-((S)-sec-butyl)-8-(2-carboxyethyl)-5-isopropyl-14-((E)-2-(methylsulfonyl)vinyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid
InChIKey: VEKNUYSRYFYBQI-ITUQAALSSA-N
SMILES: O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Biological Activity: NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC50 value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease [1].
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NWL-117 | NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC50 value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease . | |||||||||||||||||||||
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