2270986-66-6
Chemical Structure
CL2 Linker
- CAS No.: 2270986-66-6
- Formula:C68H103N11O22
- Molecular Weight:1426.61
IUPAC Name: 4-((29S,32S)-29-benzyl-32-(4-((tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxoprop
InChIKey: BGFZCTPREVDQQQ-YQOHNZFASA-N
SMILES: OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O
Biological Activity: CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CL2 Linker | CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours). | |||||||||||||||||||||
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References
- [1]. Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26. [Content Brief]
- [2]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. [Content Brief]
