227449-73-2
227449-73-2
Chemical Structure
Syk Inhibitor II dihydrochloride
- CAS No.: 227449-73-2
- Formula:C14H17Cl2F3N6O
- Molecular Weight:413.23
IUPAC Name: 2-((2-aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide dihydrochloride
InChIKey: OWOVYLSSMDVDIW-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl
Biological Activity: Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect[1].
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Syk Inhibitor II dihydrochloride | Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect. | |||||||||||||||||||||
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