2287153-38-0
Chemical Structure
APJ receptor agonist 1
- CAS No.: 2287153-38-0
- Formula:C31H26ClN3O3
- Molecular Weight:524.01
IUPAC Name: (S)-2'-(1H-benzo[d]imidazol-2-yl)-6'-chloro-4-(((R)-1-phenylbutyl)carbamoyl)-[1,1'-biphenyl]-2-carboxylic acid
InChIKey: KCWRZNXFHSFVKD-RUZDIDTESA-N
SMILES: O=C(C1=CC(C(N[C@@H](C2=CC=CC=C2)CCC)=O)=CC=[C@]1[C@]3=C(Cl)C=CC=C3C4=NC5=CC=CC=C5N4)O
Biological Activity: APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1].
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APJ receptor agonist 1 | APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure. | |||||||||||||||||||||
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