22884-10-2
22884-10-2
Chemical Structure
Imidazol-1-yl-acetic acid
- CAS No.: 22884-10-2
- Formula:C5H6N2O2
- Molecular Weight:126.11
IUPAC Name: 2-(1H-imidazol-1-yl)acetic acid
InChIKey: QAFBDRSXXHEXGB-UHFFFAOYSA-N
SMILES: O=C(O)CN1C=CN=C1
Biological Activity: Imidazol-1-yl-acetic acid is a BRS-3 agonist that mediates anorectic effects through activation of orphan G protein-coupled receptors (Orphan GPCR) in peripheral tissues; it also serves as a green, water-soluble, recyclable bifunctional organocatalyst for transformations such as Biginelli multicomponent reactions and epoxide ring opening. Imidazol-1-yl-acetic acid is used in the study of obesity[1][2][3][4][5].
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Imidazol-1-yl-acetic acid | 99.91% | Imidazol-1-yl-acetic acid is a BRS-3 agonist that mediates anorectic effects through activation of orphan G protein-coupled receptors (Orphan GPCR) in peripheral tissues; it also serves as a green, water-soluble, recyclable bifunctional organocatalyst for transformations such as Biginelli multicomponent reactions and epoxide ring opening. Imidazol-1-yl-acetic acid is used in the study of obesity. | ||||||||||||||||||||
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Imidazol-1-yl-acetic acid (Standard) | ≥98% | Imidazol-1-yl-acetic acid (Standard) is the analytical standard of Imidazol-1-yl-acetic acid (HY-W010448). This product is intended for research and analytical applications. Imidazol-1-yl-acetic acid is a BRS-3 agonist that mediates anorectic effects through activation of orphan G protein-coupled receptors (Orphan GPCR) in peripheral tissues; it also serves as a green, water-soluble, recyclable bifunctional organocatalyst for transformations such as the Biginelli multicomponent reaction and epoxide ring opening. Imidazol-1-yl-acetic acid can be used for research on obesity. | ||||||||||||||||||||
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References
- [1]. Kiyotsuka Y, et al. Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists. Bioorganic & medicinal chemistry letters. 2016 Sep 01;26(17):4205-10.
- [2]. Singh SK, et al. Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid. Beilstein journal of organic chemistry. 2008;4:42.
- [3]. Simin Nazari, et al. Imidazol-1-yl-acetic acid as a novel green bifunctional organocatalyst for the synthesis of 1,8-dioxooctahydroxanthenes under solvent-free conditions, Chinese Chemical Letters, Volume 25, Issue 2, 2014, Pages 317-320, ISSN 1001-8417.
- [4]. Mojgan Kargar, et al. Efficient and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones using imidazol-1-yl-acetic acid as a novel, reusable and water-soluble organocatalyst, Catalysis Communications, Volume 15, Issue 1, 2011, Pages 123-126, ISSN 1566-7367.
- [5]. Nazari S, et al. Imidazol-1-yl-acetic Acid as a Green Simple Bifunctional Organocatalyst for the Regioselective Conversion of Epoxides to 1, 2-azido Alcohols and β-hydroxythiocyanates[J]. Current Organocatalysis, 2014, 1(1): 7-12.
