2300106-50-5
2300106-50-5
Chemical Structure
JAK3 covalent inhibitor-1
- CAS No.: 2300106-50-5
- Formula:C22H17FN6O2S
- Molecular Weight:448.47
IUPAC Name: N-((1R,3S)-3-cyanamido-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-3-fluorobenzenesulfonamide
InChIKey: MLJSOTTYIVCEQO-VQTJNVASSA-N
SMILES: O=S(N[C@H](C[C@@H]1NC#N)C(C1=C2)=CC=C2C3=C4C(NC=C4)=NC=N3)(C5=CC=CC(F)=C5)=O
Biological Activity: JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].
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JAK3 covalent inhibitor-1 | JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. | |||||||||||||||||||||
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