2300178-72-5
2300178-72-5
Chemical Structure
Kevetrin-13C2,15N3 hydrochloride
Synonym(s): 4-Isothioureidobutyronitrile-13C2,15N3 hydrochloride; thioureidobutyronitrile-13C2,15N3 hydrochloride
- CAS No.: 2300178-72-5
- Formula:C313C2H10Cl15N3S
- Molecular Weight:184.64
IUPAC Name: 3-(cyano-13C-15N)propyl carbamimidothioate-13C-15N2 hydrochloride
InChIKey: NCXJZJFDQMKRKM-CBWHUSCUSA-N
SMILES: [15NH2][13C](SCCC[13C]#[15N])=[15NH].Cl
Biological Activity: Kevetrin (hydrochloride)-13C2,15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kevetrin-13C2,15N3 hydrochloride | Kevetrin (hydrochloride)-13C2,15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. | |||||||||||||||||||||
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Kevetrin hydrochloride | 98.0% | Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells. | ||||||||||||||||||||
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SKF 91488 dihydrochloride | 98.62% | SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension. | ||||||||||||||||||||
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VUF 8430 | VUF 8430 is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM. | |||||||||||||||||||||
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AE-ITU dihydrobromide | 98.0% | AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats. | ||||||||||||||||||||
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Thioarginine hydrobromide | 99.9% | Thioarginine hydrobromide is a colorimetric substrate for arginase that can be used in the spectrophotometric assay of arginase. | ||||||||||||||||||||
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Kevetrin | Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that exhibits p53-dependent and p53-independent antitumor activity. In TP53 wild-type models, Kevetrin activates and stabilizes the p53 protein by altering the processing of MDM2, thereby inducing cell cycle arrest and apoptosis. Kevetrin shows higher sensitivity in mutant models. Kevetrin is applicable for the research of various cancers including acute myeloid leukemia and breast cancer. | |||||||||||||||||||||
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Cyanoethyl dimethyldithiocarbamate | 97.01% | Cyanoethyl dimethyldithiocarbamate, a dithiocarbamate-related substance, is a contact allergen. Cyanoethyl dimethyldithiocarbamate can be found in accelerator-free and conventional nitrile gloves. Cyanoethyl dimethyldithiocarbamate can be used for the research of allergic contact dermatitis. | ||||||||||||||||||||
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Dimaprit dihydrochloride | 99.14% | Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion. | ||||||||||||||||||||
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4-Aminobutanenitrile hydrochloride | 4-Aminobutanenitrile hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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2-(Carbamimidoylsulfanyl)acetic acid hydrochloride | 2-(Carbamimidoylsulfanyl)acetic acid hydrochloride is a thiourea compound and an Isothiourea derivative, with potential antidiabetic activity. | |||||||||||||||||||||
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