2300981-68-2
Chemical Structure
SKLB-C05
- CAS No.: 2300981-68-2
- Formula:C23H23ClN2O2
- Molecular Weight:394.89
IUPAC Name: (S)-1-(4-(1-aminopropan-2-yl)phenyl)-2-hydroxy-4-methylphenanthridin-6(5H)-one hydrochloride
InChIKey: YZYCGODEQAXOET-PFEQFJNWSA-N
SMILES: O=C1NC2=C(C)C=C(O)C(C3=CC=C(C=C3)[C@H](CN)C)=C2C4=C1C=CC=C4.Cl
Biological Activity: SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer[1].
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SKLB-C05 | SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer. | |||||||||||||||||||||
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