2304692-48-4
2304692-48-4
Chemical Structure
Donidalorsen
Synonym(s): ISIS-721744 free acid; IONIS-PKK-LRX free acid
- CAS No.: 2304692-48-4
- Formula:C296H435N83O151P20S15
- Molecular Weight:8672.64
SMILES: [Donidalorsen]
Biological Activity: Donidalorsen (ISIS-721744; IONIS-PKK-LRX free acid) is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen can be used in the research of hereditary angioedema[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Donidalorsen | 98.39% | Donidalorsen (ISIS-721744; IONIS-PKK-LRX free acid) is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen can be used in the research of hereditary angioedema. | ||||||||||||||||||||
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References
- [1]. Petersen RS, et al. A phase 2 open-label extension study of prekallikrein inhibition with donidalorsen for hereditary angioedema. Allergy. 2024;79(3):724-734. [Content Brief]
- [2]. Diep JK, et al. Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. CPT Pharmacometrics Syst Pharmacol. 2026;15(2):e70206. [Content Brief]
