2304701-45-7
2304701-45-7
Chemical Structure
Donidalorsen sodium
Synonym(s): ISIS-721744; IONIS-PKK-LRX
- CAS No.: 2304701-45-7
- Formula:C296H435N83Na20O151P20S15
- Molecular Weight:8672.6 (free acid)
SMILES: [Donidalorsen (sodium)]
Biological Activity: Donidalorsen (ISIS-721744; IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Donidalorsen sodium | 95.90% | Donidalorsen (ISIS-721744; IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema. | ||||||||||||||||||||
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References
- [1]. Petersen RS, et al. A phase 2 open-label extension study of prekallikrein inhibition with donidalorsen for hereditary angioedema. Allergy. 2024;79(3):724-734. [Content Brief]
- [2]. Diep JK, et al. Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. CPT Pharmacometrics Syst Pharmacol. 2026;15(2):e70206. [Content Brief]
