2305204-24-2
2305204-24-2
Chemical Structure
PA-915
Synonym(s): PAC1R antagonist 1
- CAS No.: 2305204-24-2
- Formula:C17H17ClN6O2
- Molecular Weight:372.81
IUPAC Name: 4-iodo-1-(trifluoromethyl)-1H-pyrazole
InChIKey: MCXQHNLGSHUYBL-UHFFFAOYSA-N
SMILES: O=C(C1CC(N(C1)C2=NNC3=C2C=CC=C3Cl)=O)NCCC4=CNC=N4
Biological Activity: PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain[1].
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PA-915 | 99.17% | PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain. | ||||||||||||||||||||
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