2305379-66-0
2305379-66-0
Chemical Structure
BRD7-IN-1 free base
- CAS No.: 2305379-66-0
- Formula:C22H26N4O3
- Molecular Weight:394.47
IUPAC Name: 4-(3,5-dimethoxy-4-(piperazin-1-ylmethyl)phenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
InChIKey: NWXABBDHVJBGQH-UHFFFAOYSA-N
SMILES: CN1C=C(C2=CC(OC)=C(CN3CCNCC3)C(OC)=C2)C(C=CN=C4)=C4C1=O
Biological Activity: BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1].
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BRD7-IN-1 free base | BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively). | |||||||||||||||||||||
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