2305607-45-6
2305607-45-6
Chemical Structure
Sotigalimab
Synonym(s): APX005M; APX005M; EPI-0050
- CAS No.: 2305607-45-6
- Formula:N/A
- Molecular Weight:(144.54 kDa)
IUPAC Name: 6-(6-amino-5-methoxypyridin-3-yl)-3-(4-fluorobenzyl)benzo[d]oxazol-2(3H)-one
SMILES: [Sotigalimab]
Biological Activity: Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sotigalimab | 98.90% | Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma. | ||||||||||||||||||||
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References
- [1]. Mark H O'Hara, et al. CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study. Lancet Oncol. 2021 Jan;22(1) [Content Brief]
- [2]. Weiss SA, et al. A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy. Clin Cancer Res. 2024 Jan 5;30(1):74-81. [Content Brief]
