2306193-99-5
Chemical Structure
VH032-cyclopropane-F
Synonym(s): VHL ligand 3; E3 ligase Ligand 19
- CAS No.: 2306193-99-5
- Formula:C26H33FN4O5S
- Molecular Weight:532.63
IUPAC Name: (2S,4R)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: OKBLHQUBMCCFKE-LVCYWYKZSA-N
SMILES: O=C(NCC1=CC=C(C=C1O)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O
Biological Activity: VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VH032-cyclopropane-F | 99.92% | VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4. | ||||||||||||||||||||
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