2309931-05-1
2309931-05-1
Chemical Structure
ONO-AE3-208 sodium salt
Synonym(s): AE 3-208 sodium salt
- CAS No.: 2309931-05-1
- Formula:C24H20FN2NaO3
- Molecular Weight:426.42
InChIKey: FTOXXPATZUZQCF-UHFFFAOYSA-M
SMILES: FC1=CC=C(C2=CC=CC=C21)C(C)C(NC3=CC(C#N)=CC=C3CCCC(O[Na])=O)=O
Biological Activity: ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].
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ONO-AE3-208 sodium salt | ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer. | |||||||||||||||||||||
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References
- [1]. Kenji Kabashima, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109(7):883-93. [Content Brief]
- [2]. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8. [Content Brief]
