2310304-72-2
2310304-72-2
Chemical Structure
Rac1-IN-6
- CAS No.: 2310304-72-2
- Formula:C26H32N6O
- Molecular Weight:444.57
InChIKey: BCEGLHWWRPEZLG-UHFFFAOYSA-N
SMILES: CCN1C2=C(C=C(NC3=NC(NCCCN4CCOCC4)=NC(C)=C3)C=C2)C5=C1C=CC=C5
Biological Activity: Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM)[1].
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Rac1-IN-6 | Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM). | |||||||||||||||||||||
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