2322264-11-7
Chemical Structure
Ilaprazole sodium hydrate
Synonym(s): IY-81149 sodium hydrate
- CAS No.: 2322264-11-7
- Formula:C19H21N4NaO4S
- Molecular Weight:424.45
InChIKey: ZQGDDMFDBZPGCD-UHFFFAOYSA-N
SMILES: CC1=C(OC)C=CN=C1CS(C2=NC3=CC(N4C=CC=C4)=CC=C3[N-]2)=O.[Na+]
Biological Activity: Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2].
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Ilaprazole sodium hydrate | 99.15% | Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor. | ||||||||||||||||||||
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References
- [1]. Kwon D, et al. Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo. Arzneimittelforschung. 2001;51(3):204-213. [Content Brief]
- [2]. Zheng M, et al. Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase. Oncotarget. 2017;8(24):39143-39153. [Content Brief]
