2326428-24-2
2326428-24-2
Chemical Structure
CDK7-IN-2 hydrochloride hydrate
- CAS No.: 2326428-24-2
- Formula:C26H42ClN7O4
- Molecular Weight:552.11
IUPAC Name: (S,E)-1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl 4-((3-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)amino)piperidine-1-carboxylate hydrochloride hydrate
InChIKey: XHTUBUFFXLGQAJ-STEWLIJWSA-N
SMILES: O=C(N1CCC(NC2=CC(C)=NC3=C(C(C)C)C=NN23)CC1)O[C@@H]4CN(C(/C=C/CN(C)C)=O)CC4.O.Cl
Biological Activity: CDK7-IN-2 hydrochloride hydrate (Example 6) is a potent and selective CDK7 inhibitor. CDK7-IN-2 has potent anti-cancer activity[1][2].
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CDK7-IN-2 hydrochloride hydrate | CDK7-IN-2 hydrochloride hydrate (Example 6) is a potent and selective CDK7 inhibitor. CDK7-IN-2 has potent anti-cancer activity. | |||||||||||||||||||||
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References
- [1]. Georgina P Sava, et al. CDK7 inhibitors as anticancer drugs. Cancer Metastasis Rev. 2020 May 8. [Content Brief]
- [2]. David Andrew Coates, et al. (e)-1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl 4-((3-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)amino)piperidine-1-carboxylate for inhibiting cdk7, US20200017513A1.
