2334525-50-5
Chemical Structure
TD-428
- CAS No.: 2334525-50-5
- Formula:C43H43ClN10O7S
- Molecular Weight:879.38
IUPAC Name: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(3-(2-(2-(2-((3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-5-yl)amino)ethoxy)ethoxy)ethoxy)phenyl)acetamide
InChIKey: XEZUBGASURUNMF-CDRRMRQFSA-N
SMILES: O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
Biological Activity: TD-428 is a BRD4/BET PROTAC degrader. TD-428 induces the degradation of BRD4 and BET proteins via the ubiquitin-proteasome pathway by recruiting cereblon, thereby inhibiting C-MYC transcription and cancer cell proliferation. TD-428 can be used in the research of metastatic castration-resistant prostate cancer and prostate cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TD-428 | 98.81% | TD-428 is a BRD4/BET PROTAC degrader. TD-428 induces the degradation of BRD4 and BET proteins via the ubiquitin-proteasome pathway by recruiting cereblon, thereby inhibiting C-MYC transcription and cancer cell proliferation. TD-428 can be used in the research of metastatic castration-resistant prostate cancer and prostate cancer. | ||||||||||||||||||||
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References
- [1]. Lee J, et al. Discovery of E3 Ligase Ligands for Target Protein Degradation. Molecules (Basel, Switzerland). 2022 Oct 02;27(19):6515.
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[2]. Sung Ah Kim, et al. A novel cereblon modulator for targeted protein degradation, European Journal of Medicinal Chemistry, Volume 166, 2019, Pages 65-74, ISSN 0223-5234.
