2341740-84-7
Chemical Structure
BI-3663
- CAS No.: 2341740-84-7
- Formula:C44H42F3N7O12
- Molecular Weight:917.84
IUPAC Name: N-(2-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)ethyl)-3-methoxy-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide
InChIKey: ADTXLFJKQHYGPM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCOCCOCCOCCNC(C4=CC=C(NC5=NC=C(C(F)(F)F)C(OC6=CC=CC(CC7)=C6C7=O)=N5)C(OC)=C4)=O
Biological Activity: BI-3663 is a highly selective PTK2/FAK PROTAC (DC50 = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC50 value of 18 nM. BI-3663 is a PROTAC generated by linking the PTK2/FAK inhibitor BI-4464 (HY-124625) with a Pomalidomide (HY-10984) derivative via a linker. BI-3663 can induce PTK2 degradation at low nanomolar concentrations. BI-3663 has antitumor activity[1].
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BI-3663 | 99.84% | BI-3663 is a highly selective PTK2/FAK PROTAC (DC50 = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC50 value of 18 nM. BI-3663 is a PROTAC generated by linking the PTK2/FAK inhibitor BI-4464 (HY-124625) with a Pomalidomide (HY-10984) derivative via a linker. BI-3663 can induce PTK2 degradation at low nanomolar concentrations. BI-3663 has antitumor activity. | ||||||||||||||||||||
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BI-3663 (Standard) | ≥98% | BI-3663 (Standard) is the analytical standard of BI-3663 (HY-111546). This product is intended for research and analytical applications. BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker. Anti-cancer activity. | ||||||||||||||||||||
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