2341935-88-2
Chemical Structure
AChE/MAO-B-IN-9
- CAS No.: 2341935-88-2
- Formula:C21H20FN3O3
- Molecular Weight:381.40
InChIKey: KHEZCYFTTUDDEB-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=C(O1)C=CC(F)=C2)=O)NC3=CC=C(N4CCN(C)CC4)C=C3
Biological Activity: AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC50 of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease[1].
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AChE/MAO-B-IN-9 | AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC50 of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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