2345648-39-5
2345648-39-5
Chemical Structure
MAP3K1-IN-1
- CAS No.: 2345648-39-5
- Formula:C20H14F4N6O
- Molecular Weight:430.36
InChIKey: IRYXIGIWUXQBGT-UHFFFAOYSA-N
SMILES: CN1C=C(C2=NC3=CC(NC(NC4=CC(C(F)(F)F)=C(F)C=C4)=O)=CC=C3N=C2)C=N1
Biological Activity: MAP3K1-IN-1 is an orally active and selective MAP3K1 kinase inhibitor. MAP3K1-IN-1 blocks TNFα-induced phosphorylation of IKKβ and activation of NF-κB. MAP3K1-IN-1 inhibits the growth of cancer cells. MAP3K1-IN-1 induces a decrease in phosphorylation sites of NPM1. MAP3K1-IN-1 can be used in pancreatic cancer-related research[1].
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MAP3K1-IN-1 | MAP3K1-IN-1 is an orally active and selective MAP3K1 kinase inhibitor. MAP3K1-IN-1 blocks TNFα-induced phosphorylation of IKKβ and activation of NF-κB. MAP3K1-IN-1 inhibits the growth of cancer cells. MAP3K1-IN-1 induces a decrease in phosphorylation sites of NPM1. MAP3K1-IN-1 can be used in pancreatic cancer-related research. | |||||||||||||||||||||
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