2349329-01-5
2349329-01-5
Chemical Structure
MG16
- CAS No.: 2349329-01-5
- Formula:C23H22ClN3O6
- Molecular Weight:471.89
InChIKey: WZAGABULANQAJD-BQAIUKQQSA-N
SMILES: CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC=C(C=C5C=C4CN3C2=O)OC)=O)OC(CN)=O.Cl
Biological Activity: MG16 is a prodrug of 10-Methoxycamptothecin (HY-N0446). MG16 downregulates CDK6 and upregulates ASK1. MG16 induces cell cycle arrest and Apoptosis. MG16 exhibits anticancer activity against Lewis lung carcinoma, small cell lung cancer, and non-small cell lung cancer[1].
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MG16 | MG16 is a prodrug of 10-Methoxycamptothecin (HY-N0446). MG16 downregulates CDK6 and upregulates ASK1. MG16 induces cell cycle arrest and Apoptosis. MG16 exhibits anticancer activity against Lewis lung carcinoma, small cell lung cancer, and non-small cell lung cancer. | |||||||||||||||||||||
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