2358754-27-3
Chemical Structure
PDE4-IN-2
- CAS No.: 2358754-27-3
- Formula:C23H26N2O3
- Molecular Weight:378.46
IUPAC Name: (S)-6,7-dimethoxy-1-(2-(6-methyl-1H-indol-3-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carbaldehyde
InChIKey: OIDQRHGTWLIKKZ-NRFANRHFSA-N
SMILES: CC1=CC2=C(C=C1)C(CC[C@H]3C(C=C4OC)=C(CCN3C=O)C=C4OC)=CN2
Biological Activity: PDE4-IN-2 is an orally active and selective PDE4D inhibitor with a human IC50 of 0.24 μM. PDE4-IN-2 blocks cAMP hydrolysis, elevates cAMP, and inhibits inflammatory cytokine release. PDE4-IN-2 exhibits higher selectivity for PDE4D over PDE1-3 and PDE5-11. PDE4-IN-2 shows high cell permeability and weak inhibitory effect on hERG. PDE4-IN-2 prevents Imiquimod (HY-B0180)-induced psoriasis-like skin lesions. PDE4-IN-2 can be used in psoriasis-related research[1].
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PDE4-IN-2 | PDE4-IN-2 is an orally active and selective PDE4D inhibitor with a human IC50 of 0.24 μM. PDE4-IN-2 blocks cAMP hydrolysis, elevates cAMP, and inhibits inflammatory cytokine release. PDE4-IN-2 exhibits higher selectivity for PDE4D over PDE1-3 and PDE5-11. PDE4-IN-2 shows high cell permeability and weak inhibitory effect on hERG. PDE4-IN-2 prevents Imiquimod (HY-B0180)-induced psoriasis-like skin lesions. PDE4-IN-2 can be used in psoriasis-related research. | |||||||||||||||||||||
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