2361124-03-8
Chemical Structure
Claziprotamidum
Synonym(s): Claziprotamide; BBP-671
- CAS No.: 2361124-03-8
- Formula:C19H20ClFN4O
- Molecular Weight:374.84
InChIKey: GGZFNPBICDFCKG-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C(C2CC2)C(F)=C1)N3CCN(CC3)C4=NN=C(C=C4)Cl
Biological Activity: Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Claziprotamidum | 98.33% | Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia. | ||||||||||||||||||||
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References
- [1]. Tangallapally R, et al. Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J Med Chem. 2024;67(16):14432-14442. [Content Brief]
- [2]. Subramanian C, et al. Pantothenate Kinase Activation Restores Brain Coenzyme A in a Mouse Model of Pantothenate Kinase-Associated Neurodegeneration. J Pharmacol Exp Ther. 2024;388(1):171-180. Published 2024 Jan 2. [Content Brief]
- [3]. Subramanian C, et al. Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia. J Inherit Metab Dis. 2023;46(1):28-42. [Content Brief]
