2364429-77-4
2364429-77-4
Chemical Structure
RORγt Inverse agonist 3
- CAS No.: 2364429-77-4
- Formula:C29H31Cl2N5O4S
- Molecular Weight:616.56
IUPAC Name: (S)-1-((2,4-dichloro-3-(((2-isopropyl-4-(1-methyl-1H-imidazol-5-yl)quinolin-8-yl)oxy)methyl)phenyl)sulfonyl)-N-methylpyrrolidine-2-carboxamide
InChIKey: LQMIVDIAZXZEPL-QHCPKHFHSA-N
SMILES: CC(C)C1=NC2=C(C=CC=C2OCC3=C(Cl)C=CC(S(=O)(N4CCC[C@H]4C(NC)=O)=O)=C3Cl)C(C5=CN=CN5C)=C1
Biological Activity: RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively[1].
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RORγt Inverse agonist 3 | 99.92% | RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively. | ||||||||||||||||||||
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