2365073-59-0
2365073-59-0
Chemical Structure
TR79
- CAS No.: 2365073-59-0
- Formula:C26H26F3N5O2
- Molecular Weight:497.51
InChIKey: OBXSBENVSGXISV-UHFFFAOYSA-N
SMILES: NCCCN(C1=C(CN(CC2=CC=CC(C#N)=C2)CC1)C(N3CC4=CC=C(C(F)(F)F)C=C4)=O)C3=O
Biological Activity: TR79 is a mitochondrial ClpP protease activator with an EC50 of 414.49 nM. TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation. TR79 can be used in research on mitochondria-related diseases (such as cancer and neurodegenerative diseases) and mitochondrial metabolic abnormalities[1][2].
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TR79 | TR79 is a mitochondrial ClpP protease activator with an EC50 of 414.49 nM. TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation. TR79 can be used in research on mitochondria-related diseases (such as cancer and neurodegenerative diseases) and mitochondrial metabolic abnormalities. | |||||||||||||||||||||
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References
- [1]. Chen C, et al. Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond. JACS Au. 2026 Sep 28;6(9):5439-5454. [Content Brief]
- [2]. Yamada W, et al. Targeted protein degradation in the mitochondrial matrix and its application to chemical control of mitochondrial morphology. Chem Sci. 2024 Aug 28;15(36):14625-14634. [Content Brief]
