2365161-92-6
2365161-92-6
Chemical Structure
C5aR1 antagonist 2
- CAS No.: 2365161-92-6
- Formula:C29H30F3N3O2
- Molecular Weight:509.56
InChIKey: ONKTXFDNNPZTSN-UHFFFAOYSA-N
SMILES: O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(N1C4CCN(CC4)C5=C(C)C=CC=C5C)C=CC=C3OC
Biological Activity: C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases[1].
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C5aR1 antagonist 2 | C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases. | |||||||||||||||||||||
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