2365241-79-6
2365241-79-6
Chemical Structure
PI4KIIIbeta-IN-11
- CAS No.: 2365241-79-6
- Formula:C33H39N7O3
- Molecular Weight:581.71
IUPAC Name: (S)-N-(1-hydroxypropan-2-yl)-5-(5-(2-hydroxypropan-2-yl)-2-methyl-7-((3-(1-methyl-1H-imidazol-2-yl)benzyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-N,2-dimethylbenzamide
InChIKey: LGILUCRVDGGDMI-NRFANRHFSA-N
SMILES: CN1C(C2=CC=CC(CNC3=CC(C(C)(O)C)=NC4=C(C5=CC(C(N(C)[C@@H](C)CO)=O)=C(C=C5)C)C(C)=NN34)=C2)=NC=C1
Biological Activity: PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum[1][2].
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PI4KIIIbeta-IN-11 | PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum. | |||||||||||||||||||||
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References
- [1]. Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. [Content Brief]
- [2]. Barton Nicholas Paul, et al. Preparation of pyrazolopyrimidinamines derivatives as PI4kIII-beta inhibitors: World Intellectual Property Organization, WO2019141694. 2019-07-25.
