2365497-07-8
2365497-07-8
Chemical Structure
ALK/ROS1-IN-1
- CAS No.: 2365497-07-8
- Formula:C30H35F3N6O3
- Molecular Weight:584.63
IUPAC Name: (S)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide
InChIKey: JQWJRFOFKDLCQB-QFIPXVFZSA-N
SMILES: O=C([C@H]1CCCN(C2=CC(NC3=CC=C(N4CCNCC4)C=C3OC)=NC=C2)C1)NCC5=CC=C(OC(F)(F)F)C=C5
Biological Activity: ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.
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ALK/ROS1-IN-1 | ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively. | |||||||||||||||||||||
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