2366272-43-5
2366272-43-5
Chemical Structure
(4aS,8aR)-NPD-001
- CAS No.: 2366272-43-5
- Formula:C33H40N6O4
- Molecular Weight:584.71
IUPAC Name: L-prolyl-L-lysyl-L-glutamyl-L-lysine
InChIKey: DNDNLFXKQSTINI-WUFINQPMSA-N
SMILES: O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[C@@]6([H])CC=CC[C@@]16[H]
Biological Activity: (4aS,8aR)-NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS,8aR)-NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS,8aR)-NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS,8aR)-NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882[1].
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(4aS,8aR)-NPD-001 | (4aS,8aR)-NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS,8aR)-NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS,8aR)-NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS,8aR)-NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882. | |||||||||||||||||||||
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